Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. PubChem CID: Chemical Names: Eudragit RS; ; Ethyl prop- 2-enoate; methyl 2-methylpropenoate;. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.

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Time-controlled release – Evonik Industries AG

Drug eudragit rspo from GC and GD matrix followed zero order and Higuchi square root kinetics respectively. The dried granules were sized by a mesh sieve and after lubrication with magnesium stearate.

Questions or comments about MatWeb? Results of the present study demonstrated that combination of both synthetic hydrophilic Eudragit RSPO with natural hydrophobic polymers GC and CD could be successfully employed for formulating sustainedrelease matrix tablets.

Matrix systems are widely used in oral eudragit rspo drug delivery because of their flexibility, cost effectiveness, low influence of eudragit rspo physiological variables on its release behavior and broad regulatory acceptance [ 67 ]. Please review our privacy policy.

The samples withdrawn were filtered through a 0. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. Add to My Bibliography. The prepared matrix tablets eudragit rspo evaluated for hardness, weight variation, thickness, friability and drug content [ 19 ]. This may be due to the reason that the gums in higher concentrations in the tablets might have produced dense matrix around the drug particles, providing more barriers for them to escape and dissolve.

Generate a file for eudragit rspo with external citation management software. The influence of the polymer concentration in the tablets was also investigated. Supplemental Content Full text links. To describe the kinetics of drug release from matrix tablets, release data was analyzed according to different kinetic equations. Further, such dense matrix, specifically when it is hydrophobic in nature, may be expected to favor less penetration of the dissolution medium in the tablets.

The compound has relatively short plasma half-life of 1. The granules were eudragit rspo for angle of repose, loose bulk density LBDtapped bulk density TBDcompressibility index and drug content. Fitting the in vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.


The results showed probability eudragit rspo dose dumping from matrix tablets prepared without GC and GD. Abstract Lobenzarit disodium is a drug for the treatment eudragit rspo rheumatoid arthritis. Hydrophilic eudragit when combined with hydrophobic GC and GD FX-FXV no eudragit rspo release was observed, which may be due to the tendency to mask these quaternary ammonium eudragit rspo to some extent, thereby modifying release eudragit rspo the drug.

Eudragit rspo data were analyzed by the regression coefficient method and regression coefficient values r 2 of eudragit rspo batches were shown in Table 4. The overall objective of this study was to develop an oral sustained release metformin hydrochloride tablet by using hydrophilic Eudragit RSPO alone or its combination with hydrophobic natural polymers Gum copal and gum damar as rate controlling factor.

Time-controlled Drug release

Mumbai, Indiaand gum copal and gum damar were received as a gift sample from Imex Inc. Users requiring more precise data for scientific or engineering calculations can click on the property value to see the original value as well as raw conversions to equivalent units. Hausner’s values of the prepared granules ranged from 1. Infrared spectrum was taken by scanning the samples of eudragit rspo drug and the rxpo individually over a wave number range of to cm —1 using Fourier transform infrared spectrophotometer FT-IR, Shimadzu S, Shimadzu, Eudragit rspo.

Table 3 eudragit rspo the physical parameters such as hardness, thickness, friability and weight uniformity of all the fabricated tablets.

Evonik EUDRAGIT® RS PO Copolymer

Eudragit RSPO contains quaternary ammonium groups, and solubilization of these quaternary ammonium groups in acidic pH leads to formation eudragit rspo pores in the matrix, thereby releasing metformin HCl in the acidic pH. Diffusion coupled with erosion might be the mechanism for the drug release from hydrophilic and hydrophobic polymer based matrix tablets which dudragit be expected to reduce the eudragit rspo sudragit administration and decrease eeudragit dose-dependent side effects associated with repeated administration of conventional metformin HCl Tablets.


Eudragit rspo of Pharmacy, Kamptee, Nagpur, India for providing necessary facilities to carry out this work.

An obstacle to more successful use of metformin therapy is the high incidence of concomitant gastrointestinal symptoms, such as abdominal discomfort, nausea, and diarrhea that especially occurs during the initial period of treatment. An angle of repose of less than eudragitt degrees indicates good flow properties. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct eudragit rspo using Ethocel and Eudragit RS-PO as polymeric materials in different ratios.

As regards the effect of gum concentration, rsppo in drug release rate was observed when GC and GD content in the matrix were increased. The natural materials have been extensively used eudragit rspo the field of drug delivery because they are readily available, cost-effective, eco-friendly, capable of multitude of chemical modifications, potentially degradable and compatible eudragit rspo to their natural origin [ 16 ].

Hausner’s ratio was related eduragit interparticle friction and could be used to predict powder flow properties. Sustained release eudragit rspo that would maintain plasma level for h might be sufficient for daily dosing of metformin. To confirm the diffusion mechanism, the data were fitted into Korsmeyer-Peppas equation [ 23 ]. MatWeb is intended eudragit rspo personal, non-commercial use.

Prior to compression, granules were evaluated for their flow and compressibility characteristics. Hence, in the present work, an attempt has been made to formulate the extendedrelease matrix tablets of metformin HCl using hydrophilic polymer Eudragit RSPO alone or in combination with hydrophobic natural polymer, GC and GD to evaluate eudragitt in vitro release characteristics and to predict the release eudragit rspo.

We advise that you only use the original value or one of its raw conversions in your calculations eudragit rspo minimize eudragit rspo error. All other ingredients used throughout the study were of analytical grade and were used as received.